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Updated: Mar 28, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Hyponatraemia in patients with multiple myeloma
Eitan Mirvis1, Dunnya De-Silva1, Atul Mehta1
1Lysosomal Storage Disorders Unit, Department of Haematology, Royal Free Hospital, London, UK.
Hyponatraemia, a common clinical issue, can stem from multiple factors, including iatrogenic water intoxication. This case series highlights hyponatraemia in multiple myeloma patients, detailing causes and management strategies.
Area of Science:
- Nephrology
- Internal Medicine
- Clinical Pathology
Background:
- Hyponatraemia is the most frequent electrolyte imbalance in clinical settings.
- The causes of hyponatraemia are diverse and often multifactorial.
- Iatrogenic water intoxication is a significant, yet often overlooked, cause of hyponatraemia.
Observation:
- Presents three distinct cases of patients diagnosed with multiple myeloma.
- Each case illustrates unique facets of hyponatraemia development and presentation.
- Highlights the complexity of diagnosing and managing hyponatraemia in this patient cohort.
Findings:
- Demonstrates varied aetiologies of hyponatraemia in multiple myeloma.
- Illustrates challenges in differentiating causes, including water intoxication.
- Emphasizes the need for tailored management strategies based on individual patient factors.
Implications:
- Enhances understanding of hyponatraemia in multiple myeloma patients.
- Provides insights into managing complex electrolyte disturbances.
- Informs clinical practice regarding prevention and treatment of iatrogenic hyponatraemia.
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