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Morphologic and regulatory aspects of prostatic function.

G Aumüller1

  • 1Department of Anatomy and Cell Biology, Philipps-Universität, Federal Republic of Germany.

Anatomy and Embryology
|January 1, 1989
PubMed
Summary
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The human prostate has distinct zones and a functional unit concept aids understanding growth. Androgen and estrogen balance, growth factors, and aging influence prostate health and diseases like BPH and cancer.

Area of Science:

  • Urology
  • Endocrinology
  • Histology

Background:

  • The human prostate's structure and function are understood through endocrine principles.
  • Embryological and histological studies reveal four prostatic subdivisions: anterior fibromuscular stroma, periurethral, peripheral, and central zones.
  • A functional prostatic unit concept integrates stroma-epithelium interactions for growth and gene expression.

Purpose of the Study:

  • To present current concepts of human prostate structural and functional organization.
  • To relate these concepts to endocrine principles.
  • To provide a framework for understanding prostatic pathologies.

Main Methods:

  • Review of embryological and histological studies.
  • Analysis of functional interdependence between stroma and epithelium.

Related Experiment Videos

  • Consideration of hormonal influences (androgen, estrogen) and growth factors.

    • Main Results:

    • The prostate is divided into four zones: anterior, periurethral, peripheral (75%), and central (25%).
    • Functional heterogeneity exists, with estrogen-sensitive cells near the urethra and undifferentiated acini peripherally.
    • Secretory and proliferative activities are androgen-dependent.

    Conclusions:

    • The functional prostatic unit concept explains growth and gene expression.
    • Hormonal imbalances, growth factors, and aging are key factors in prostatic pathologies.
    • Understanding these elements is crucial for addressing benign prostatic hyperplasia and prostate cancer.