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Related Experiment Video

Updated: Jun 23, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

Published on: May 23, 2015

Screening for lung cancer.

¹Center for Health Policy Research and Education, Duke University, Durham, North Carolina.

Annals of Internal Medicine

|August 1, 1989

Summary

This summary is machine-generated.

Lung cancer screening using chest X-rays and sputum cytology does not reduce mortality in smokers. These tests offer minimal benefit but lead to false positives, making lung cancer screening not recommended.

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Last Updated: Jun 23, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules

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Published on: May 23, 2015

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Area of Science:

Oncology
Pulmonology
Preventive Medicine

Background:

Lung cancer is a leading cause of cancer death globally.
Incidence and mortality rates, particularly in women, are rising.
Current screening methods include chest roentgenography and sputum cytology.

Purpose of the Study:

To evaluate the effectiveness of lung cancer screening in reducing mortality.
To assess the benefits and harms of chest roentgenography and sputum cytology for lung cancer screening.

Main Methods:

Analysis of four controlled trials and one case-control study.
Review of data from the Mayo Lung Project comparing screened high-risk men with a control group.

Main Results:

Screening did not demonstrate a reduction in lung cancer mortality.
The Mayo Lung Project showed similar mortality rates between screened and control groups.
False-positive rates for chest roentgenography and sputum cytology were approximately 5% and 0.5%, respectively.

Conclusions:

Current evidence does not support lung cancer screening with chest roentgenography or sputum cytology.
Potential harms and costs outweigh the demonstrated benefits.
Lung cancer screening is not recommended for high-risk individuals based on existing data.