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Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Is the Fgap1 mediated response to oxidative stress chemotype dependent in Fusarium graminearum?
Mathilde Montibus1, Claire Khosravi2, Enric Zehraoui2
1INRA, UR1264 MycSA, 71, Avenue Edouard Bourlaux, CS20032, F-33882 Villenave d'Ornon Cedex, France mathilde.montibus@gmail.com.
Abstract:
This study aims to compare the role of the transcription factor Fgap1 in oxidative stress response for two Fusarium graminearum strains belonging to the two chemotypes DON/ADON and NIV/FX. While the response to H2O2 was shown to be chemotype dependent, an opposite result was observed for diamide: whatever the chemotype, the global level of TCTB (i.e. trichothecene B) production was strongly increased by the treatment with diamide. Fgap1 was shown to be involved in this regulation for both chemotypes. Our data show that the response to diamide is mediated by Fgap1 whatever the chemotype of the F. graminearum strains. However, the NIV/FX chemotype has developed higher antioxidant capacities in response to oxidative stress. But when this capacity is overwhelmed by an increment in the H2O2 level, the NIV/FX strains also responds by an increase in toxin accumulation.
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