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Cherubism With Bilateral Mandible and Maxilla Involvement: A Case Report
Zhaoyang Yu1, Miao Zhai, Wei Gan
1From the Department of Radiology and Pharmacy, Shandong Power Central Hospital (ZY, MZ, WG, HZ, HW); and Department of Gynaecology and Obstetrics, Women and Children Health Care Hospital of Shandong Province, Shandong, China (YZ).
Medicine
|December 15, 2015
Summary
Cherubism is a rare pediatric fibro-osseous condition. This case highlights a non-familial instance affecting both the mandible and maxilla, aiding early diagnosis.
Area of Science:
- Pediatric Dentistry
- Oral Pathology
- Genetics
Background:
- Cherubism is a rare, nonneoplastic, self-limiting fibro-osseous condition typically affecting children.
- It is often familial and characterized by bilateral mandibular lesions.
- Histologically, it involves the replacement of bone with fibrovascular tissue containing multinucleated giant cells.
Observation:
- A 4-year-old female presented with slowly enlarging, painless, symmetrical swelling of both cheeks.
- This presentation was unusual as it was non-familial and involved both the mandible and maxilla.
- Clinical examination revealed significant facial swelling.
Findings:
- The case presented is a non-familial form of cherubism.
- The condition involved both the mandible and the maxilla, expanding beyond the typical mandibular presentation.
- Imaging and biopsy confirmed the diagnosis.
Implications:
- This case expands the understanding of cherubism's clinical presentation, including non-familial instances and maxillary involvement.
- Early diagnosis through computed tomography scans and biopsy is crucial for management.
- Further research into the genetic and etiological factors of non-familial cherubism is warranted.
