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Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
Richard H Kramer1, Christopher M Davenport1
1Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, United States of America.
Abstract:
Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery.
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