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Coronary flow reserve/diastolic function relationship in angina-suffering patients with normal coronary angiography

Chiara Anchisi1, Giuliano Marti, Ilaria Bellacosa

  • 1aCardiology Clinic bLaboratory of Physiology and Experimental Surgery, Department of Translational Medicine, Università del Piemonte Orientale 'A. Avogadro,' AOU 'Maggiore della Carità', Novara, Italy.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|December 15, 2015
PubMed

Insights

In patients with angina and normal coronary arteries, reduced coronary flow reserve (CFR) is linked to diastolic dysfunction. This suggests a direct relationship between impaired CFR and diastolic function when both are altered.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Diagnostic Imaging

Background:

  • Coronary blood flow and diastolic function are intricately linked via mechanical and metabolic pathways.
  • Understanding this relationship is crucial in patients presenting with angina despite normal coronary angiograms.

Purpose of the Study:

  • To investigate the association between coronary flow reserve (CFR) and diastolic dysfunction.
  • To analyze these parameters in patients experiencing angina with angiographically normal coronary arteries.

Main Methods:

  • Employed transthoracic echo-Doppler to measure CFR via dipyridamole-induced hyperemia in 16 patients.
  • Assessed diastolic function (E/A, deceleration time, IVRT, Vp) and left ventricular mass using 2D echocardiography.

Main Results:

  • Patients were grouped by CFR (altered vs. unaltered) and then by combined CFR and diastolic function.
  • The 'altered CFR/diastole' (AA) and 'normal CFR/altered diastole' (NA) groups showed significant findings.
  • Older age and normal body weight were noted in the altered CFR (ACFR) and AA groups compared to others.

Conclusions:

  • Reduced CFR and diastolic dysfunction are correlated specifically in patients with concurrent alterations in both variables.
  • The findings suggest a direct link between altered CFR and diastolic function, independent of shared risk factors.
Abstract

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