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Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations.

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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
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Devil Facial Tumor Disease.

R J Pye1, G M Woods2, A Kreiss1

  • 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Veterinary Pathology
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

Devil facial tumor disease (DFTD) is a contagious cancer threatening Tasmanian devils with extinction. Research has uncovered its cause, transmission, and impact, informing conservation efforts for this unique species.

Keywords:
Schwann cellTasmanian devilallograftdevil facial tumor diseasegeneticsimmune evasionimmune responsetransmissible cancertumor escape

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Area of Science:

  • Veterinary medicine
  • Wildlife conservation
  • Cancer research

Background:

  • Devil facial tumor disease (DFTD) is a transmissible cancer endangering Tasmanian devils.
  • DFTD is the only known contagious cancer affecting wildlife.
  • The species faces extinction due to DFTD.

Purpose of the Study:

  • To review current knowledge on DFTD.
  • To explore the disease's cause, pathogenesis, and transmission.
  • To contextualize findings within conservation strategies.

Main Methods:

  • Literature review of DFTD research.
  • Analysis of disease impacts on devils and the ecosystem.
  • Synthesis of information for conservation planning.

Main Results:

  • Significant progress in understanding DFTD's cause and pathogenesis.
  • Insights into devil immune responses and tumor immune evasion.
  • Data on DFTD transmission patterns and ecological effects.

Conclusions:

  • DFTD research has advanced considerably in 10 years.
  • Understanding DFTD is crucial for developing effective conservation strategies.
  • Mitigating DFTD's impact is vital for Tasmanian devil survival.