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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Assessing "First Mile" Supply Chain Factors Affecting Timeliness of School-Based Deworming Interventions: Supply and

Kimberly M Koporc1, Eric Strunz1, Cassandra Holloway1

  • 1Children Without Worms, Task Force for Global Health, Decatur, Georgia, United States of America.

Plos Neglected Tropical Diseases
|December 15, 2015
PubMed

Insights

Children Without Worms (CWW) evaluated drug donation programs for soil-transmitted helminthiasis (STH) control. Most mass drug administrations (MDAs) were on time, but supply chain issues caused delays or missed treatments, impacting coverage.

Area of Science:

  • Global Health
  • Infectious Disease Epidemiology
  • Pharmaceutical Supply Chain Management

Background:

  • Children Without Worms (CWW) managed Johnson & Johnson's mebendazole donations for school-aged children to combat soil-transmitted helminthiasis (STH) from 2007-2012.
  • The study reviewed program data from 14 STH-endemic countries to identify factors influencing mass drug administration (MDA) timeliness and supply chain performance in drug donation programs.

Purpose of the Study:

  • To identify factors associated with on-time, delayed, or missed mass drug administration (MDA) interventions.
  • To explore potential indicators for evaluating supply chain performance in drug donation programs for neglected tropical diseases (NTDs).

Main Methods:

  • Program data, including drug applications, shipping records, and annual treatment reports, were tracked using Microsoft Excel.
  • Qualitative data from key personnel interviews provided context for delays or missed MDAs.
  • Four potential factors were examined: production, shipping, customs clearance, and in-country issues. Coverage rates were calculated based on targeted vs. administered treatments.

Main Results:

  • Out of 78 approved requests, 54 MDAs (69%) were implemented on time or early.
  • 13% of MDAs were delayed, with most by one month or less.
  • 18% of MDAs were missed, and the mean coverage for on-time or delayed MDAs was approximately 88%.

Conclusions:

  • Four key performance indicators for supply chain management in NTD drug donation programs were identified.
  • These indicators include donor inventory availability, timely shipment of requested doses, timely arrival at central medical stores, and scheduled MDA implementation by country programs.
  • These metrics can help assess and improve supply chain processes for future drug donation initiatives.
Abstract

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