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Probiotics in digestive diseases: focus on Lactobacillus GG
1Head Complex Operating Unit of Gastroenterology, "Bolognini" Hospital, Seriate, Bergamo, Italy - fabio.pace@bolognini.bg.it.
Minerva Gastroenterologica E Dietologica
|December 15, 2015
Summary
Probiotics, live microorganisms conferring health benefits, are increasingly popular for gut health. Lactobacillus GG (LGG) is a well-documented probiotic strain effective for various gastrointestinal disorders.
Area of Science:
- Gastroenterology and Microbiology
- Focus on probiotics and their role in digestive health.
Background:
- Probiotics are live microorganisms providing health benefits.
- Their popularity is growing in both research and consumer markets.
- They can benefit both healthy individuals and those with existing conditions.
Purpose of the Study:
- To explore the growing interest in probiotics.
- To review evidence for probiotics in digestive diseases like IBS, IBD, and NAFLD.
- To assess the specific strain Lactobacillus GG (LGG) for gastrointestinal tract disorders.
Main Methods:
- Review of animal and human studies on probiotics for GIT diseases (1990s-2014).
- Literature search using PubMed, Medline, and Ovid.
- Analysis of probiotic strain characteristics, including Lactobacillus GG (LGG).
Main Results:
- Probiotics are promising for modulating the gut microbiota and treating dysbiosis.
- LGG demonstrates high adhesion, resistance to gastric acid, and antimicrobial activity.
- LGG shows persistence in the human GIT and evidence for preventing/relieving diarrhea and treating C. difficile colitis.
Conclusions:
- Probiotics, particularly strains like LGG, are valuable for managing gastrointestinal disorders.
- LGG is a well-characterized probiotic with proven efficacy and adaptability to the GIT.
- Further clinical data is needed, but probiotics represent a promising therapeutic avenue.
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