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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Diastolic heart failure: diagnosis and therapy
Alina Nicoara1, Mandisa Jones-Haywood
1Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Current Opinion in Anaesthesiology
|December 15, 2015
Summary
Heart failure with preserved ejection fraction (HFpEF), or diastolic heart failure (DHF), is increasingly common. Effective treatments remain elusive due to its complex nature and varied causes.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Diastolic heart failure (DHF), now known as heart failure with preserved ejection fraction (HFpEF), is the most prevalent form of heart failure.
- While diastolic dysfunction is a key factor, HFpEF is recognized as a complex clinical condition with diverse pathophysiology and significant input from extracardiac comorbidities.
Purpose of the Study:
- To review recent findings in the diagnosis and treatment of diastolic heart failure (DHF) or heart failure with preserved ejection fraction (HFpEF).
Main Methods:
- Literature review of recent findings in DHF/HFpEF diagnosis and treatment.
Main Results:
- HFpEF is a complex entity with heterogeneous pathophysiology and extracardiac comorbidities.
- Ventricular-arterial coupling alterations impact exercise hemodynamics; absence of diastolic dysfunction at rest does not rule out HFpEF.
- Limited progress in evidence-based treatments for HFpEF is attributed to pathophysiological heterogeneity and clinical trial design.
Conclusions:
- Understanding HFpEF's phenotypic heterogeneity and multifactorial pathophysiology may reveal future therapeutic targets.
- Current management of HFpEF relies on aggressive treatment of contributing factors.
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