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Updated: Mar 28, 2026
Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
Published on: May 16, 2022
Syntheses and biomedical applications of hollow micro-/nano-spheres with large-through-holes
Yinsong Si1, Min Chen1, Limin Wu1
1Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, P. R. China. chenmin@fudan.edu.cn lmw@fudan.edu.cn.
Abstract:
Hollow micro-/nano-spheres with large-through-holes in shells (denoted as HMLS) have demonstrated great potential in biomedical applications owing to the combination of hollow structure and their porous shells. In this review, we provide a comprehensive overview of synthesis methods of HMLS obtained from the template-directed approach, shell-breaking method, Ostwald ripening and galvanic replacement primarily based on the formation mechanism of the large-through-holes in the shell. We further discuss the biomedical applications of HMLS including guest adsorption and encapsulation of proteins, drug/gene delivery, biomedical imaging, and theranostics. We conclude this review with some perspectives on the future research and development of the HMLS with desired morphologies and properties.
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