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Updated: Mar 28, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Published on: September 27, 2019

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GRPR/PI3Kγ: Partners in Central Transmission of Itch

Paula J S Pereira1, Gustavo D B Machado2, Giuliano M Danesi2

  • 1Programa de Pós-graduação em Biologia Celular e Molecular, Instituto de Toxicologia e Farmacologia, Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 15, 2015
PubMed
Summary

The gastrin-releasing peptide receptor (GRPR) transmits itch signals via the PI3Kγ/Akt pathway. Inhibiting this pathway offers a potential new treatment for chronic itch conditions.

Keywords:
AS605240GRPRPI3Kγdry skinitchspinal cord

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