Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.6K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
5.9K
MicroRNAs01:22

MicroRNAs

4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2026
Same author

Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis.

Bone & joint open·2026
Same author

Age-related real-world treatment patterns and outcomes of localised, high-grade osteosarcoma.

Journal of bone oncology·2026
Same author

Deep learning-based auto-contouring for organs at risk in three-dimensional image-guided brachytherapy for cervical cancer and endometrial cancer.

Journal of applied clinical medical physics·2026
Same author

Analysis of the Relationship Between Survival and Postoperative Infection in Patients With Osteosarcoma.

Journal of surgical oncology·2026
Same author

High-risk soft-tissue sarcomas in elderly patients: does perioperative radiotherapy improve local control and prognosis?

BMC cancer·2026

Related Experiment Video

Updated: Mar 28, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K

microRNAs and Soft Tissue Sarcomas.

Tomohiro Fujiwara1,2, Toshiyuki Kunisada3,4, Ken Takeda3,5

  • 1Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. tomomedvn@gmail.com.

Advances in Experimental Medicine and Biology
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) show promise as biomarkers for soft tissue sarcomas. These small RNAs, found in tumors and blood, could improve diagnosis and treatment prediction for these challenging cancers.

Keywords:
BiomarkerSoft tissue sarcomaTherapeuticsmicroRNA

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

3.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

3.0K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Soft tissue sarcomas are diverse cancers originating from mesenchymal tissues.
  • Current diagnostic methods face challenges due to histological subtype heterogeneity.
  • A critical clinical need exists for reliable biomarkers for early detection and treatment response prediction.

Purpose of the Study:

  • To review the emerging evidence of microRNA (miRNA) dysregulation in soft tissue sarcomas.
  • To discuss the potential of miRNAs as diagnostic and prognostic biomarkers.
  • To explore miRNAs as novel therapeutic targets in soft tissue sarcoma management.

Main Methods:

  • Literature review of studies investigating miRNAs in soft tissue sarcoma tissues.
  • Analysis of research on circulating miRNAs in sarcoma patients' blood.
  • Synthesis of current findings on miRNA dysregulation and clinical relevance.

Main Results:

  • MicroRNAs are frequently dysregulated in soft tissue sarcoma tissues.
  • Altered miRNA expression is detectable in the blood of sarcoma patients.
  • These findings highlight the potential of miRNAs as accessible biomarkers.

Conclusions:

  • MicroRNAs represent a promising class of biomarkers for soft tissue sarcomas.
  • Further research can validate miRNAs for clinical applications in diagnosis and treatment.
  • miRNAs may offer new avenues for targeted therapies in sarcoma care.