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Working with Human Tissues for Translational Cancer Research
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Translational Research in Pediatrics IV: Solid Tissue Collection and Processing.

Carolina Gillio-Meina1, H Ronald Zielke2, Douglas D Fraser3

  • 1Translational Research Centre, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada;

Pediatrics
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

Collecting solid tissues from children for research requires careful ethical consideration and optimal handling to ensure specimen quality. RNA integrity number is the new standard for assessing tissue quality, alongside comprehensive clinical data.

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Area of Science:

  • Pediatric research
  • Biomedical research
  • Tissue engineering

Background:

  • Solid tissues are crucial for child-health research, obtained via biopsy, surgery, or postmortem donation.
  • Ethical considerations and optimal handling are vital for maximizing the quality of pediatric tissue specimens.
  • Factors like age, BMI, and processing methods can impact tissue integrity.

Purpose of the Study:

  • To review ethical standards for pediatric solid tissue procurement.
  • To identify potential sources of pediatric research tissues.
  • To outline optimal practices for tissue processing, handling, storage, and quality assessment.

Main Methods:

  • Review of ethical guidelines and scientific literature on pediatric tissue handling.
  • Analysis of factors affecting tissue quality (e.g., fixation, storage, postmortem interval).
  • Evaluation of current and emerging methods for assessing tissue integrity.

Main Results:

  • Ethical procurement from children presents unique challenges.
  • Various factors can compromise tissue quality, including nucleotide degradation and altered protein stability.
  • RNA integrity number and housekeeping gene analysis are the new standards for tissue quality assessment.

Conclusions:

  • Adherence to ethical standards and optimized handling protocols are essential for high-quality pediatric research tissues.
  • Comprehensive clinical data accompanying samples is imperative for accurate research outcomes.
  • Implementing standardized quality control measures ensures the reliability of findings from pediatric solid tissue research.