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Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous

Jacqueline A Hannam1, Xavier Borrat1, Iñaki F Trocóniz1

  • 1Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain (J.A.H., I.F.T.); Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland, New Zealand (J.A.H.); Systems Pharmacology Effect Control and Modeling Research Group, Department of Anesthesia, Hospital CLINIC de Barcelona, Barcelona, Spain (X.B., J.F.V., A.P., P.L.G.); Electronic Engineering Program, School of Engineering. Universidad de San Buenaventura, Cali, Colombia (J.F.V.); Centre for Biomedical Engineering Research, Universitat Politècnica de Catalunya, Barcelona, Spain (E.W.J.); Gastroenterology Department, Hospital CLINIC, CIBERehd, Institut d'investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain (J.M., S.C.-B., A.C.); Department of Anesthesia and Perioperative Care, University of California, San Francisco, California (P.L.G.); and Neuroimmunology Research Group, Institut d'investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain (P.L.G.).

The Journal of Pharmacology and Experimental Therapeutics
|December 15, 2015
PubMed

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