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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
Published on: March 1, 2016
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Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell
E L Lee1, H H Bendre1, A Kalmykov1
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Journal of Materials Chemistry. B
|December 15, 2015
Abstract:
Current cell sheet-based blood vessels lack biomimetic structure and require excessively long culture times that may compromise smooth muscle cell phenotype. We modified a commercially available product for uniaxial cell sheet conditioning with thermoresponsive copolymers. Thus, culture of detachable conditioned cell sheets is shortened while retaining structural integrity and contractility.
