Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

109
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
109
Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.6K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

76
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
76
Genetic Lingo01:11

Genetic Lingo

117.6K
Overview
117.6K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

94
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
94

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Prediction of new-onset migraine using clinical-genotypic data from the HUNT Study: a machine learning analysis.

The journal of headache and pain·2025
Same author

Breaking barriers: noncanonical inflammasome executes blood-brain barrier disruption.

Signal transduction and targeted therapy·2024
Same author

Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system.

Immunity·2024
Same author

Innate immune memory after brain injury drives inflammatory cardiac dysfunction.

Cell·2024
Same author

Rational correction of pathogenic conformational defects in HTRA1.

Nature communications·2024

Related Experiment Video

Updated: Mar 28, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.2K

The migraine-stroke connection: A genetic perspective.

Rainer Malik1, Bendik Winsvold2, Eva Auffenberg3

  • 1Institute for Stroke and Dementia Research (ISD), Munich, Germany.

Cephalalgia : an International Journal of Headache
|December 15, 2015
PubMed
Summary

Genetic factors link migraine and vascular diseases. Research explores shared molecular mechanisms in conditions like CADASIL and familial hemiplegic migraine, with potential implications for stroke and cardiovascular disease.

Keywords:
CADASILcortical spreading depressiongenetic susceptibilitygenomewide association studyhemiplegic migrainemigraine pathophysiologymouse model

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

3.2K

Related Experiment Videos

Last Updated: Mar 28, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.2K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

3.2K

Area of Science:

  • Neurology
  • Genetics
  • Vascular Biology

Background:

  • A complex relationship between migraine and vascular disease is recognized.
  • The underlying pathophysiological mechanisms remain incompletely understood.

Purpose of the Study:

  • To review the genetic perspective of the migraine-vascular disorders connection.
  • To illustrate potentially shared molecular mechanisms.

Main Methods:

  • Summarize clinical presentation and genetic basis of monogenic vascular syndromes (e.g., CADASIL) with migraine.
  • Discuss data from transgenic mouse models for familial hemiplegic migraine.
  • Review genome-wide association studies (GWAS) for overlapping findings.

Main Results:

  • Monogenic vascular syndromes like CADASIL manifest with prominent migraine.
  • Cortical spreading depression in mouse models may link migraine and ischemic stroke.
  • GWAS reveal overlapping genetic findings between migraine and cervical artery dissection, ischemic stroke, and cardiovascular disease.

Conclusions:

  • Substantial evidence supports a genetic link between migraine and vascular disease.
  • Advancements in high-throughput data, genotyping, and phenotyping are expected to yield further insights.