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The migraine-stroke connection: A genetic perspective

Rainer Malik1, Bendik Winsvold2, Eva Auffenberg3

  • 1Institute for Stroke and Dementia Research (ISD), Munich, Germany.

Cephalalgia : an International Journal of Headache
|December 15, 2015
PubMed

Insights

Genetic factors link migraine and vascular diseases. Research explores shared molecular mechanisms in conditions like CADASIL and familial hemiplegic migraine, with potential implications for stroke and cardiovascular disease.

Area of Science:

  • Neurology
  • Genetics
  • Vascular Biology

Background:

  • A complex relationship between migraine and vascular disease is recognized.
  • The underlying pathophysiological mechanisms remain incompletely understood.

Purpose of the Study:

  • To review the genetic perspective of the migraine-vascular disorders connection.
  • To illustrate potentially shared molecular mechanisms.

Main Methods:

  • Summarize clinical presentation and genetic basis of monogenic vascular syndromes (e.g., CADASIL) with migraine.
  • Discuss data from transgenic mouse models for familial hemiplegic migraine.
  • Review genome-wide association studies (GWAS) for overlapping findings.

Main Results:

  • Monogenic vascular syndromes like CADASIL manifest with prominent migraine.
  • Cortical spreading depression in mouse models may link migraine and ischemic stroke.
  • GWAS reveal overlapping genetic findings between migraine and cervical artery dissection, ischemic stroke, and cardiovascular disease.

Conclusions:

  • Substantial evidence supports a genetic link between migraine and vascular disease.
  • Advancements in high-throughput data, genotyping, and phenotyping are expected to yield further insights.
Abstract

Keywords:
CADASILcortical spreading depressiongenetic susceptibilitygenomewide association studyhemiplegic migrainemigraine pathophysiologymouse model

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