Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

5.2K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
5.2K
ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

6.8K
The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
6.8K
ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

10.4K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
10.4K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

6.9K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
6.9K
Active Transport01:14

Active Transport

2.6K
Active transport is a critical biological process that allows cells to move solutes against an electrochemical gradient. This process requires direct energy input and is characterized by its selectivity, saturability, and susceptibility to competitive inhibition.
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...
2.6K
Primary Active Transport01:47

Primary Active Transport

205.6K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
205.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanosensitive Piezo1 Channels in Enamel Cells.

Calcified tissue international·2026
Same author

CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

K<sub>ATP</sub> channels and cardioprotection.

Arhiv za farmaciju·2025
Same author

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development.

Frontiers in immunology·2024
Same author

Do K<sub>ATP</sub> channels have a role in immunity?

Frontiers in immunology·2024
Same author

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Mar 28, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.8K

KATP Channels in the Cardiovascular System.

Monique N Foster1, William A Coetzee1

  • 1Departments of Pediatrics, Physiology & Neuroscience, and Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, New York.

Physiological Reviews
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

This review details ATP-sensitive potassium (KATP) channels, crucial for cell function. It explores their cardiovascular roles, molecular makeup, and links to heart disease, highlighting ongoing research.

More Related Videos

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
12:48

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

Published on: February 19, 2013

11.2K
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
08:33

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time

Published on: March 11, 2021

2.4K

Related Experiment Videos

Last Updated: Mar 28, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.8K
Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
12:48

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

Published on: February 19, 2013

11.2K
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
08:33

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time

Published on: March 11, 2021

2.4K

Area of Science:

  • Cardiovascular Physiology and Molecular Biology
  • Ion Channel Research

Background:

  • ATP-sensitive potassium (KATP) channels are vital for cellular functions across numerous tissues.
  • While known for decades, their complex physiological and pathophysiological roles are still being elucidated.
  • Electrophysiology has detailed their biophysical and pharmacological properties, but biological regulation remains an active area of study.

Purpose of the Study:

  • To review the properties, molecular composition, and pharmacology of KATP channels within the cardiovascular system.
  • To summarize findings from genetic mouse models concerning KATP channel function.
  • To discuss the involvement of KATP channels in cardiovascular diseases and the impact of genetic variations.

Main Methods:

  • Literature review and synthesis of existing research on KATP channels.
  • Analysis of data from genetic mouse models.
  • Examination of clinical and genetic studies related to cardiovascular pathologies.

Main Results:

  • KATP channels exhibit diverse roles in cardiac atria, conduction system, ventricles, smooth muscle, endothelium, and mitochondria.
  • Genetic mouse models have provided insights into tissue-specific functions and disease relevance.
  • Genetic variations in KATP channel genes are linked to human cardiovascular diseases.

Conclusions:

  • KATP channels are critical regulators of cardiovascular function and are implicated in various heart conditions.
  • Further research into KATP channel regulation and pharmacology holds therapeutic potential for cardiovascular diseases.
  • Understanding genetic variations in KATP channels is essential for personalized medicine approaches in cardiology.