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Modulation in Natriuretic Peptides System in Experimental Colitis in Rats
Chang Ho Lee1, Gi Won Ha1, Jong Hun Kim2
1Department of Surgery, Research Institute for Endocrine Sciences, Chonbuk National University Medical School, Jeonju, Korea.
Digestive Diseases and Sciences
|December 15, 2015
Summary
Atrial natriuretic peptide (ANP) enhances its inhibitory effect on colonic motility in experimental colitis. This suggests the natriuretic peptide system plays a role in colitis pathophysiology, potentially via increased natriuretic peptide receptor-A mRNA.
Area of Science:
- Gastroenterology
- Physiology
- Pharmacology
Background:
- The renin-angiotensin system is implicated in colonic inflammation.
- Limited research exists on the natriuretic peptide system's role in this context.
Purpose of the Study:
- Investigate the existence of a local atrial natriuretic peptide (ANP) system in the rat colon.
- Determine ANP's role in regulating colonic motility during experimental colitis.
Main Methods:
- Experimental colitis induced using 5% dextran sulfate sodium (DSS) in rats.
- Measured plasma hormone concentrations and natriuretic peptide system mRNA levels.
- Assessed colonic motility response to ANP in isolated taenia coli.
Main Results:
- DSS-treated rats exhibited increased colonic necrosis and inflammation.
- Colonic natriuretic peptide receptor-A mRNA and particulate guanylyl cyclase activity increased, while ANP and natriuretic peptide receptor-B mRNA decreased.
- ANP dose-dependently reduced basal colonic motility frequency, an effect enhanced in DSS-treated rats.
Conclusions:
- The augmented inhibitory effect of ANP on basal colonic motility in experimental colitis may stem from increased colonic natriuretic peptide receptor-A mRNA expression.
- The local natriuretic peptide system appears to be partially involved in the pathophysiology of experimental colitis.
