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The role of HOX genes in head and neck squamous cell carcinoma

Christopher Platais1, Fahad Hakami1,2, Lav Darda1

  • 1Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|December 15, 2015
PubMed

Insights

HOX genes, crucial in embryonic development, are frequently altered in head and neck squamous cell carcinoma (HNSCC). Research suggests HOX genes may serve as novel biomarkers and therapeutic targets for HNSCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Head and neck squamous cell carcinoma (HNSCC) exhibits numerous genomic and transcriptomic alterations.
  • Current therapeutic targets and biomarkers for HNSCC are limited, necessitating the identification of new molecular characteristics.
  • Aberrant expression of HOX genes, involved in embryonic development, is frequently observed in HNSCC gene expression profiles.

Purpose of the Study:

  • To review the biology of HOX genes in cancer.
  • To summarize evidence for HOX gene involvement in HNSCC development.
  • To evaluate HOX genes as potential therapeutic targets for HNSCC.

Main Methods:

  • Literature review of studies on HOX gene expression in HNSCC.
  • Analysis of the role of HOX genes in cellular processes relevant to cancer.
  • Appraisal of current and future pharmacological interventions targeting HOX genes.

Main Results:

  • HOX genes are implicated in developmental patterning and morphogenesis.
  • Aberrant HOX gene expression is a common feature in HNSCC.
  • HOX genes regulate cellular proliferation and migration, processes critical in cancer development.

Conclusions:

  • HOX genes play a significant role in HNSCC development.
  • HOX genes represent promising candidates for novel HNSCC biomarkers and therapeutic targets.
  • Further research is needed to elucidate specific HOX gene functions and optimize pharmacological strategies.
Keywords:
HOX genesHomeoboxhead and neck cancerhead and neck squamous cell carcinoma

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