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Culture of Brain Capillary Pericytes for Cytosolic Calcium Measurements and Calcium Imaging Studies
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What is a pericyte?

David Attwell1, Anusha Mishra2, Catherine N Hall3

  • 1Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK d.attwell@ucl.ac.uk.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

Pericytes regulate brain blood flow and can limit it after stroke. Discrepancies in research stem from differing definitions of pericyte subtypes, highlighting the need for a unified classification for stroke therapies.

Keywords:
Pericyteblood–brain barriercapillarycerebral blood flowstroke

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Area of Science:

  • Neuroscience
  • Vascular Biology
  • Cell Biology

Background:

  • Pericytes are contractile cells on capillaries crucial for regulating cerebral blood flow.
  • Pericytes have been implicated in limiting blood flow post-ischemia, potentially leading to cell death.
  • Recent studies present conflicting views on the role of pericytes in cerebral blood flow regulation.

Purpose of the Study:

  • To reconcile conflicting findings regarding pericyte function in cerebral blood flow.
  • To investigate the impact of differing pericyte definitions on research outcomes.
  • To advocate for an objective classification of pericyte subtypes.

Main Methods:

  • Comparative analysis of existing literature on pericyte function.
  • Examination of differing definitions and classifications of pericytes across studies.
  • Review of physiological and pathological roles of pericytes in cerebral circulation.

Main Results:

  • Discrepancies in pericyte research arise from inconsistent definitions of pericyte subtypes.
  • Earlier data confirming pericyte roles in cerebral blood flow are consistent with current findings when definitions are harmonized.
  • A lack of objective pericyte sub-classification hinders therapeutic development.

Conclusions:

  • Harmonizing pericyte definitions is essential for accurate understanding of their role in cerebral blood flow.
  • Developing objective classifications for pericyte subtypes is critical for advancing stroke and related disorder therapies.
  • Further research into distinct pericyte populations will enable targeted therapeutic strategies.