Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Why the L-type pentose pathway does not function in liver.

B R Landau1

  • 1Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

The International Journal of Biochemistry
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes.

Diabetologia·2008
Same author

Contribution of gluconeogenesis and glycogenolysis to hepatic glucose production in acromegaly before and after pituitary microsurgery.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2008
Same author

Changes in hepatic glycogen cycling during a glucose load in healthy humans.

Diabetologia·2005
Same author

Measurement of fractional whole-body gluconeogenesis in humans from blood samples using 2H nuclear magnetic resonance spectroscopy.

Diabetes·2003
Same author

Direct and indirect effects of amino acids on hepatic glucose metabolism in humans.

Diabetologia·2003
Same author

Sources of blood glycerol during fasting.

American journal of physiology. Endocrinology and metabolism·2001
Same journal

Intracellular localization of dinucleosideoligophosphate phosphorylase from Euglena gracilis.

The International journal of biochemistry·2010
Same journal

Specific phosphorylase from Euglena gracilis splits diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and diadenosine 5',5'''-P(1),P(3)-triphosphate (Ap(3)A).

The International journal of biochemistry·2010
Same journal

Immunochemical homologies among L-alpha-hydroxyacid oxidase isozymes.

The International journal of biochemistry·2010
Same journal

Biochemical characterization of hemorrhagic toxin from Crotalus viridis viridis (prairie rattlesnake) venom.

The International journal of biochemistry·1994
Same journal

The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements.

The International journal of biochemistry·1994
Same journal

Characterization of human arylsulfatase A glycans.

The International journal of biochemistry·1994
See all related articles

The classical pentose pathway, not the L-type, is active in liver metabolism. This summary revisits evidence supporting this conclusion in liver physiology.

Area of Science:

  • Biochemistry
  • Metabolic pathways
  • Liver function

Background:

  • The pentose phosphate pathway is a crucial metabolic route.
  • Distinguishing between the classical and L-type pathways is important for understanding liver metabolism.
  • Previous studies have suggested the classical pathway's dominance in the liver.

Purpose of the Study:

  • To re-evaluate and summarize the evidence for the functional pentose pathway in liver.
  • To address recent reviews that may suggest alternative interpretations.
  • To clarify the specific pathway active in hepatic cellular metabolism.

Main Methods:

  • Review and synthesis of existing literature and experimental data.
  • Analysis of isotopic tracer studies on glucose metabolism in the liver.

Related Experiment Videos

  • Comparison of metabolic flux through different pentose pathway variants.

    • Main Results:

    • The classical pentose pathway, not the L-type, is demonstrably functional in liver tissue.
    • Evidence supports the role of the classical pathway in providing NADPH and pentose sugars for hepatic processes.
    • Metabolic flux analysis confirms the dominance of the classical pathway over the L-type.

    Conclusions:

    • The classical pentose pathway is the primary functional route in liver metabolism.
    • The L-type pentose pathway does not appear to be significantly active in the liver.
    • This clarification is essential for accurate modeling of liver metabolic functions.