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Comprehensive Duloxetine Analysis in a Fatal Overdose
Kelly Ann Scanlon1, Robert Stoppacher2, Lee M Blum3
1Medical Examiner's Office, Onondaga County Health Department, Syracuse, NY, USA kellyscanlon@ongov.net.
Journal of Analytical Toxicology
|December 15, 2015
Summary
This study presents a fatal case of duloxetine toxicity, detailing the highest reported post-mortem blood concentration. Comprehensive analysis of duloxetine in various samples aids future toxicological assessments.
Area of Science:
- Pharmacology
- Forensic Toxicology
Background:
- Duloxetine, a serotonin-norepinephrine reuptake inhibitor, is widely used for depression.
- Fatalities associated with duloxetine are rare, with limited comprehensive toxicological data in overdose cases.
Observation:
- Presents a unique fatal case of duloxetine toxicity.
- Includes the highest reported post-mortem blood duloxetine concentration to date.
- Features a comprehensive toxicological analysis of duloxetine in femoral blood, vitreous humor, liver tissue, urine, and gastric contents.
Findings:
- Detailed toxicological profile of duloxetine in a fatal overdose.
- Quantification of duloxetine across multiple biological matrices.
Implications:
- Provides crucial data for forensic pathologists and toxicologists.
- Enhances the understanding of duloxetine's post-mortem distribution and toxicity.
- Aids in the interpretation of duloxetine levels in forensic investigations.