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Updated: Mar 28, 2026
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Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
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Saliva and viral infections
Periodontology 2000
|December 15, 2015
Summary
The oral virome, though understudied, includes viruses like HIV and HPV. Oral samples offer a non-invasive diagnostic method for various viral infections, aiding early detection and treatment.
Area of Science:
- Oral virology and diagnostics
- Infectious disease research
Background:
- The oral microbiome has garnered significant research interest, unlike the oral virome.
- Limited publications focus on the oral virome, necessitating further investigation.
Purpose of the Study:
- To survey viral infections, particularly those affecting or transmitted via the oral cavity.
- To highlight the diagnostic potential of oral samples for viral infections.
- To present findings on HIV detection using oral samples.
Main Methods:
- Literature review of oral viral infections.
- Focus on specific viruses transmitted or present in the oral cavity (e.g., norovirus, rabies, HPV, EBV, HSV, HCV, HIV).
- Analysis of studies utilizing lateral flow assays for HIV detection in saliva and serum.
Main Results:
- Identified key viruses prevalent in the oral cavity.
- Demonstrated the feasibility of using oral samples (saliva, swabs) for viral diagnosis.
- Showcased correlation between HIV detection in saliva and serum samples via lateral flow assays.
Conclusions:
- Oral samples are increasingly viable alternatives to blood or urine for diagnosing viral infections.
- Point-of-care devices using non-invasive oral samples can facilitate rapid, first-line diagnosis.
- Non-invasive oral diagnostics can guide appropriate patient counseling and therapeutic pathways.
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