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Published on: October 13, 2023
microRNAs and Endometrial Pathophysiology
Henry H Chill1, Uri P Dior2, Liron Kogan2
1Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel. Henchill@gmail.com.
Abstract:
Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs became prominent candidates providing missing links for many biological pathways. In recent years, microRNAs were implicated as one of the important players in regulation of various biological and physiological endometrial related processes. This chapter aims to present recent knowledge pertaining to the diverse aspects of microRNAs in the embryo-endometrial relationship. We will focus on the role of microRNAs in decidualization and their part in natural and stimulated cycles. Next, we will present recent studies deliberating the role of microRNAs in recurrent pregnancy loss and in the important phenomenon of recurrent implantation failure. Lastly, demonstrating an important aspect of embryo implantation and invasion, we will outline few microRNA related shared pathways of implantation and carcinogenesis.
Insights
MicroRNAs are key regulators in embryo implantation and endometrial processes. Understanding their role is crucial for addressing implantation failure and pregnancy loss.
Area of Science:
- Reproductive biology
- Molecular genetics
- Gynecology
Background:
- Embryo implantation involves complex interactions between the blastocyst and endometrium.
- MicroRNAs (miRNAs) have emerged as critical regulators in various biological pathways.
- Emerging evidence highlights miRNAs' significant role in endometrial function and reproductive health.
Purpose of the Study:
- To review the current understanding of microRNAs in embryo-endometrial interactions.
- To explore the function of miRNAs in decidualization and different fertility treatments.
- To discuss the involvement of miRNAs in recurrent pregnancy loss and implantation failure.
Main Methods:
- Literature review of recent studies on microRNAs in reproductive processes.
- Analysis of miRNA involvement in natural and stimulated fertility cycles.
- Examination of shared miRNA pathways in implantation and carcinogenesis.
Main Results:
- MicroRNAs play a significant role in regulating endometrial receptivity and decidualization.
- Dysregulation of specific miRNAs is linked to recurrent pregnancy loss and implantation failure.
- Shared molecular pathways involving miRNAs exist between embryo implantation and cancer development.
Conclusions:
- MicroRNAs are integral to successful embryo implantation and endometrial receptivity.
- Targeting specific miRNAs may offer therapeutic strategies for implantation disorders.
- Further research into miRNA pathways can illuminate connections between reproduction and cancer.
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