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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Related Experiment Video

Updated: Feb 26, 2026

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
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microRNAs and Endometrial Pathophysiology.

Henry H Chill1, Uri P Dior2, Liron Kogan2

  • 1Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel. Henchill@gmail.com.

Advances in Experimental Medicine and Biology
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

MicroRNAs are key regulators in embryo implantation and endometrial processes. Understanding their role is crucial for addressing implantation failure and pregnancy loss.

Keywords:
AngiogenesisDecidualizationEndometriumGynecologyImmunomodulationImplantationPregnancy

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Area of Science:

  • Reproductive biology
  • Molecular genetics
  • Gynecology

Background:

  • Embryo implantation involves complex interactions between the blastocyst and endometrium.
  • MicroRNAs (miRNAs) have emerged as critical regulators in various biological pathways.
  • Emerging evidence highlights miRNAs' significant role in endometrial function and reproductive health.

Purpose of the Study:

  • To review the current understanding of microRNAs in embryo-endometrial interactions.
  • To explore the function of miRNAs in decidualization and different fertility treatments.
  • To discuss the involvement of miRNAs in recurrent pregnancy loss and implantation failure.

Main Methods:

  • Literature review of recent studies on microRNAs in reproductive processes.
  • Analysis of miRNA involvement in natural and stimulated fertility cycles.
  • Examination of shared miRNA pathways in implantation and carcinogenesis.

Main Results:

  • MicroRNAs play a significant role in regulating endometrial receptivity and decidualization.
  • Dysregulation of specific miRNAs is linked to recurrent pregnancy loss and implantation failure.
  • Shared molecular pathways involving miRNAs exist between embryo implantation and cancer development.

Conclusions:

  • MicroRNAs are integral to successful embryo implantation and endometrial receptivity.
  • Targeting specific miRNAs may offer therapeutic strategies for implantation disorders.
  • Further research into miRNA pathways can illuminate connections between reproduction and cancer.