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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

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Updated: Mar 28, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

microRNAs and Cardiovascular Remodeling.

¹Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. kohono@kuhp.kyoto-u.ac.jp.

Advances in Experimental Medicine and Biology

|December 15, 2015

Summary

Heart failure (HF) involves cardiac remodeling, altering heart structure and function. This review examines cardiovascular remodeling mechanisms, focusing on microRNAs in HF and vascular disease progression.

Keywords:

Atherosclerosis Fibrosis Heart failure Hypertrophy Ischemia

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Last Updated: Mar 28, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

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Published on: September 15, 2018

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Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

Area of Science:

Cardiovascular Science
Molecular Biology
Pathophysiology

Background:

Heart failure (HF) causes significant morbidity and mortality due to cardiac structural changes and dysfunction.
Cardiac remodeling, the alteration of heart mass, dimensions, or shape, is a key factor in HF.
Vascular remodeling also occurs in response to hemodynamic load, cardiovascular injury, and neurohormonal activation.

Purpose of the Study:

To review the fundamental mechanisms of cardiovascular remodeling.
To explore the specific roles of microRNAs in the progression of heart failure.
To examine the involvement of microRNAs in vascular diseases.

Main Methods:

Literature review of cardiovascular remodeling.
Analysis of microRNA involvement in heart failure.
Investigation of microRNA roles in vascular pathology.

Main Results:

Cardiovascular remodeling is a critical pathogenic mechanism in heart failure.
MicroRNAs play a significant role in the progression of heart failure.
MicroRNAs are implicated in the development and progression of vascular diseases.

Conclusions:

Understanding cardiovascular remodeling mechanisms is crucial for managing heart failure.
MicroRNAs represent a key area for therapeutic intervention in heart failure and vascular diseases.