Related Experiment Video

Updated: Mar 28, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

14.6K

microRNA and Wound Healing

Jaideep Banerjee1, Chandan K Sen2

  • 1Extremity Trauma and Regenerative Medicine Division, US Army Institute of Surgical Research, 3698 Chambers Pass, BHT-1, Joint Base-San Antonio, Fort Sam Houston, San Antonio, TX, 78234, USA. jaideep.b@gmail.com.

Advances in Experimental Medicine and Biology
|December 15, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression crucial for wound healing. Targeting specific miRNAs offers potential for novel chronic wound therapies, despite challenges in identification and delivery.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Regenerative Medicine

Background:

  • MicroRNAs (miRNAs) are small noncoding RNA molecules.
  • miRNAs play critical roles in regulating gene expression.
  • These regulatory functions are vital in the complex processes of wound healing.

Purpose of the Study:

  • To explore the role of dysregulated miRNAs in chronic wound biology.
  • To identify miRNAs that can be therapeutically targeted for improved skin wound healing.
  • To discuss the challenges associated with miRNA-based therapeutic strategies.

Main Methods:

  • Review of current literature on miRNA function in wound healing.
  • Analysis of gene expression patterns regulated by miRNAs during skin repair.
  • Examination of miRNA target identification and delivery methodologies.

Main Results:

  • Specific miRNAs are implicated in the altered gene expression characteristic of chronic wounds.
  • Dysregulation of these miRNAs contributes to impaired healing.
  • Potential therapeutic targets among these miRNAs have been identified.

Conclusions:

  • Understanding miRNA dysregulation in chronic wounds is key to developing new treatments.
  • Targeting specific miRNAs holds promise for enhancing skin wound healing.
  • Overcoming challenges in miRNA target identification and delivery is essential for clinical translation.
Keywords:
AngiogenesisHypoxymiRsInflammationRe-epithelializationWound healing

More Related Videos

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

10.1K
Demonstration of the Rat Ischemic Skin Wound Model08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

22.9K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

12.0K
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
39
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.5K