Related Experiment Video

Updated: Mar 28, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.7K

Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis

Olivera Marsenic1, Michael Anderson2, Kevin G Couloures3

  • 1Department of Pediatrics, Yale University, Pediatric Nephrology, New Haven, Connecticut, USA.

Hemodialysis International. International Symposium on Home Hemodialysis
|December 15, 2015
PubMed

Insights

Lowering dialysate sodium (dNa) in pediatric hemodialysis patients improved blood pressure and fluid management. This study suggests a potential benefit of reduced dNa for children undergoing chronic hemodialysis.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Dialysis

Background:

  • Optimal dialysate sodium (dNa) concentrations for pediatric hemodialysis (HD) patients remain undetermined.
  • Adult studies suggest varying dNa levels impact outcomes, but pediatric data is lacking.

Purpose of the Study:

  • To investigate the effects of two constant dNa concentrations on pediatric chronic HD patients.
  • To assess the impact of lower dNa on clinical parameters and patient tolerance.

Main Methods:

  • A study involving 5 pediatric patients (age 4-17) on chronic HD.
  • 480 HD sessions were analyzed with dNa set at 140 mEq/L then 138 mEq/L for each patient.

Main Results:

  • Lowering dNa was linked to improved pre-HD hypertension.
  • Reduced interdialytic weight gain and decreased ultrafiltration needs were observed.
  • Lower sodium gradient was noted, with good tolerance despite variable predialysis serum sodium (sNa).

Conclusions:

  • Lowering dialysate sodium in pediatric HD patients demonstrated positive effects on blood pressure and fluid balance.
  • Further research is warranted to confirm these findings and explore even lower dNa levels for potential enhanced benefits in pediatric populations.

Keywords:
Dialysate sodiumhypertensioninterdialytic weight gainpediatric hemodialysisultrafiltration

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

3.4K

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.7K
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
373
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
462
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
620
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
738