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Smart Polymers in Nasal Drug Delivery
Ankita Chonkar1, Usha Nayak1, N Udupa1
1Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576 104, India.
Smart polymers offer a solution for nasal drug delivery by forming gels in the nose, improving drug absorption and targeting the brain. This mucoadhesive approach enhances drug retention and controlled release for better therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Science
- Drug Delivery Systems
Background:
- Nasal drug delivery is a promising route for systemic and central nervous system (CNS) drug administration.
- Nasal mucosa offers rapid absorption and bioavailability, but is limited by rapid mucociliary clearance.
- Mucoadhesive strategies are needed to prolong drug residence time on the nasal mucosa.
Purpose of the Study:
- To review stimuli-responsive polymers for enhanced nasal drug delivery.
- To discuss polymers that undergo in situ gelation in the nasal cavity.
- To highlight the benefits of smart polymers in nasal drug delivery systems.
Main Methods:
- Review of temperature-responsive, pH-responsive, and ion-responsive polymers.
- Discussion of in situ gelation mechanisms in response to nasal environment stimuli.
- Analysis of smart polymer properties for nasal drug retention and release.
Main Results:
- Stimuli-responsive polymers can transition from liquid to gel state within the nasal cavity.
- These smart polymers enhance drug retention time on the nasal mucosa.
- In situ gelation improves drug bioavailability, controlled release, and permeation.
Conclusions:
- Smart polymeric systems are effective for nasal drug delivery, overcoming mucociliary clearance.
- They offer advantages like controlled release, enhanced permeation, and protection from enzymes.
- This approach is suitable for delivering peptides, CNS drugs, and hormones via the nasal route.
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