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Polymorphisms in three genes are associated with hemorrhagic stroke.

Wenpeng Liu¹, Shichao Ge², Yan Liu¹

¹Department of Internal Medicine of Neurology People's Hospital of Jingjiang City Jingjiang 214500 Jiangsu Province China.

Brain and Behavior

|December 15, 2015

Summary

Genetic variations in RAGE, TNFRSF11B, and Golgb1 genes are linked to hemorrhagic stroke (HS) risk. Specific single nucleotide polymorphisms (SNPs) showed age-dependent associations with HS in the Chinese population.

Keywords:

Association Golgb1 gene RAGE gene TNFRSF11B gene genotype hemorrhagic stroke single nucleotide polymorphisms

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Area of Science:

Genetics
Vascular Biology
Epidemiology

Background:

Atherosclerosis and vascular diseases are potentially linked to specific genes: receptor for advanced glycation end products (RAGE), osteoprotegerin (TNFRSF11B), and Golgb1.
This study investigates the association between single nucleotide polymorphisms (SNPs) in these genes and the risk of hemorrhagic stroke (HS).

Purpose of the Study:

To determine if specific SNPs in RAGE, TNFRSF11B, and Golgb1 are associated with hemorrhagic stroke (HS) risk in a Chinese population.
To explore potential age-dependent effects of these genetic variations on HS risk.

Main Methods:

A case-control study involving 199 HS patients and 401 controls from the Chinese population.
Genotyping of SNPs (rs1035798 in RAGE, rs2073618 in TNFRSF11B, and rs3732410 in Golgb1) was performed using MassARRAY.
Statistical analysis employed logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for HS risk associated with genotypes, stratified by age (≤50 and >50 years).

Main Results:

In individuals ≤50 years, the RAGE rs1035798 C/C genotype was associated with increased HS risk, while the Golgb1 rs3732410 G/G genotype was linked to decreased risk.
In individuals >50 years, the TNFRSF11B rs2073618 G/G genotype showed an association with increased HS risk.
No significant associations were found for TNFRSF11B rs2073617 in either age group.

Conclusions:

The studied polymorphisms in RAGE, TNFRSF11B, and Golgb1 genes may play a role in hemorrhagic stroke risk.
The association of these genetic variations with HS risk appears to be age-dependent, suggesting different biological mechanisms at various life stages.