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Updated: Mar 28, 2026

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
Published on: March 15, 2024
The neuroscience of adolescent decision-making
Catherine A Hartley1, Leah H Somerville2
1Sackler Institute of Developmental Psychobiology, Weill Cornell Medical College 1300 York Avenue, Box 140, New York, NY, 10065, USA.
Abstract:
Adolescence is a phase of lifespan associated with greater independence, and thus greater demands to make self-guided decisions in the face of risks, uncertainty, and varying proximal and distal outcomes. A new wave of developmental research takes a neuroeconomic approach to specify what decision processes are changing during adolescence, along what trajectory they are changing, and what neurodevelopmental processes support these changes. Evidence is mounting to suggest that multiple decision processes are tuned differently in adolescents and adults including reward reactivity, uncertainty-tolerance, delay discounting, and experiential assessments of value and risk. Unique interactions between prefrontal cortical, striatal, and salience processing systems during adolescence both constrain and amplify various component processes of mature decision-making.
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