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Updated: Mar 28, 2026

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[Role of TRAIL in the treatment of prostate cancer: An update]

Ji-ci Ma, Qing-chuan Zhang

    Zhonghua Nan Ke Xue = National Journal of Andrology
    |December 16, 2015
    PubMed

    Insights

    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor cells, including prostate cancer cells, with minimal toxicity to normal cells. This suggests TRAIL

    Area of Science:

    • Immunology
    • Cell Biology
    • Oncology

    Background:

    • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a key regulator of apoptosis.
    • TRAIL is widely distributed in human tissues and plays a role in immune functions.
    • TRAIL receptors are present on various cell types.

    Purpose of the Study:

    • To investigate the role of TRAIL in inducing apoptosis of prostate cancer cells.
    • To evaluate the therapeutic potential of TRAIL in prostate cancer treatment.

    Main Methods:

    • Review of recent studies on TRAIL and its mechanism of action.
    • Analysis of TRAIL's effect on prostate cancer cell apoptosis.

    Main Results:

    • TRAIL effectively induces apoptosis in tumor cells.
    • TRAIL demonstrates minimal toxicity to normal cells.
    • Prostate cancer development is linked to apoptosis regulation.

    Conclusions:

    • TRAIL exhibits significant anti-tumor activity and safety.
    • TRAIL has considerable potential for the treatment of prostate cancer due to its ability to induce cancer cell apoptosis.

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