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Updated: Mar 28, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
[NON-NEOPLASTIC KIDNEY PATHOLOGY IN SPECIMENS AFTER TUMOR-RELATED NEPHRECTOMY]
Abstract:
The aim of the study was to determine the incidence of pathological changes in the unaffected parts of tumor-related nephrectomy specimens. Tissue samples obtained from 507 patients were analyzed. Non-neoplastic pathology in the tumor-free kidney tissue along with the tumor was detected in 63 (12.42%) cases. All non-tumor diseases co-existing with tumors were found in patients of older age groups. Approximately 1/3 of the non-neoplastic pathology was nephrosclerosis lesions (30.16%), and in half of those cases (52.63%) transitional cell carcinoma was detected. It is pointed out that for the detection of glomerular lesions careful microscopic examination of the unaffected parts of renal parenchyma is needed. The examination, carried out by means of special staining techniques (histochemistry, immunohistochemistry, immunofluorescence), electron microscopy, and with the involvement ofnephropathologists, can improve glomerular pathology detection rate after nephrectomy.
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