[Generation of three-dimensional pancreatic tissue from human induced pluripotent stem cells]

The functional cells or tissues derived from human induced pluripotent stem cells (iPSCs) make it possible to overcome with the insufficiency of cell sources for regenerative medicine, to investigate the precise mechanism of human organogenesis and disease, and to develop the new drugs. Especially for type 1 diabetes, making mature pancreatic beta cells from human iPSCs might have a good opportunity of regenerative medicine. However, so far in vitro, producing the fully maturated pancreatic beta cells is not achieved. Here we review the previous reports and discuss the possibility and validity of our strategy for making mature pancreatic beta cell with three-dimensional culture of pancreatic organoid derived from human iPSCs.