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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum
Wei-Hua Yuan1,2, Masuo Goto2, Kan-Yen Hsieh2,3
1a Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province , Jiangsu Normal University , Xuzhou 221116 , China.
Abstract:
One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC50 = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC50 = 5.42 ± 0.167 μM).
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