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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Unique features of long non-coding RNA biogenesis and function.

Jeffrey J Quinn1,2, Howard Y Chang1

  • 1Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California 94305, USA.

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|December 16, 2015
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key regulators in biology. This review details lncRNA life events, from transcription to function, revealing their unique characteristics and roles.

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Area of Science:

  • Molecular Biology
  • Genetics
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not encode proteins.
  • Initially considered transcriptional noise, lncRNAs are now recognized as crucial regulators of gene expression and cellular processes.
  • Their distinct features differentiate them from messenger RNAs (mRNAs).

Purpose of the Study:

  • To review the distinct life cycle events of lncRNAs.
  • To elucidate how these events contribute to lncRNA characteristics and functions.
  • To provide a comprehensive overview of lncRNA biology.

Main Methods:

  • Literature review of recent studies on lncRNA biology.
  • Analysis of lncRNA biogenesis, processing, and functional mechanisms.
  • Synthesis of information on pre-transcriptional, transcriptional, and post-transcriptional events.

Main Results:

  • lncRNAs undergo unique regulatory events before, during, and after transcription.
  • These events are critical for their stability, localization, and interaction with other molecules.
  • lncRNA functions are intricately linked to their specific life cycle stages.

Conclusions:

  • Understanding lncRNA life events is essential for deciphering their diverse biological roles.
  • lncRNAs represent a complex regulatory layer in gene expression.
  • Further research into lncRNA dynamics will uncover new therapeutic targets.