Pharmaceuticals in the environment--Global occurrences and perspectives
Tim aus der Beek1, Frank-Andreas Weber1, Axel Bergmann1
1IWW Water Centre, Department of Water Resources Management, Mülheim an der Ruhr, Germany.
Environmental Toxicology and Chemistry
|December 16, 2015
Summary
Pharmaceuticals contaminate the environment globally, with 631 substances detected across 71 countries. Urban wastewater is a major source, posing a worldwide challenge requiring collaborative management strategies.
Area of Science:
- Environmental Science
- Ecotoxicology
- Chemical Analysis
Background:
- Pharmaceuticals are ubiquitous in industrialized nations' environments.
- Data on pharmaceutical environmental concentrations in developing countries is emerging but fragmented.
- A global overview of measured environmental concentrations (MECs) for pharmaceuticals is needed.
Purpose of the Study:
- To compile and analyze global MECs of pharmaceuticals in various environmental matrices.
- To identify regional patterns and common pharmaceuticals detected worldwide.
- To assess the extent of pharmaceutical contamination across different continents and countries.
Main Methods:
- Conducted a comprehensive literature review of 1016 original publications and 150 review articles.
- Collected MEC data for human and veterinary pharmaceuticals from surface water, groundwater, drinking water, soil, and manure.
- Performed a simplified data quality assessment due to data source heterogeneity.
Main Results:
- Pharmaceuticals or their transformation products detected in 71 countries across all continents.
- 631 different pharmaceutical substances found above detection limits, with distinct regional patterns.
- Sixteen substances were detected in all 5 United Nations regions; diclofenac found in 50 countries, sometimes exceeding safe levels.
Conclusions:
- Pharmaceuticals represent a significant global environmental contamination issue.
- Urban wastewater is the primary emission pathway, with industrial, agricultural, and other sources also contributing.
- Multistakeholder approaches are essential for preventing, reducing, and managing pharmaceutical pollution.
Related Concept Videos
Pharmaceutical Poisoning: Potential Scenarios
77
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
77
Types of Toxins
4.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
4.0K
Drug Control Governance: Regulatory Bodies and Their Impact
653
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
653
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
224
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
224
Effects of Chemicals: Overview
2.4K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
2.4K
Pharmacovigilance
1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K


