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Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis
Amy J Jones1, Marcel Kaiser2, Vicky M Avery3
1Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia a.jones@griffith.edu.au.
Abstract:
The screening of a focused library identified FTY720 (Fingolimod; Gilenya) as a potent selective antitrypanosomal compound active against Trypanosoma brucei gambiense and T. brucei rhodesiense, the causative agents of human African trypanosomiasis (HAT). This is the first report of trypanocidal activity for FTY720, an oral drug registered for the treatment of relapsing multiple sclerosis, and the characterization of sphingolipids as a potential new class of compounds for HAT.
