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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
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SKAP, an outer kinetochore protein, is required for mouse germ cell development

Corinne Grey1, Julien Espeut2, Rachel Ametsitsi2

  • 1CNRSIGH (UPR1142), 141 rue de la Cardonille, 34396 Montpellier, FranceCNRSCRBM (UMR5237), 1919 route de Mende, 34293 Montpellier, FranceINRADépartement Biologie et Amélioration des Plantes, route de Saint-Cyr, 78026 Versailles, FranceCollège de FranceCIRB (UMR CNRS 7241/INSERM- U1050), 11 Place Marcelin Berthelot, 75005 Paris, FranceDepartamento de BiologíaFacultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain corinne.grey@igh.cnrs.fr bernard.de-massy@igh.cnrs.fr.

Reproduction (Cambridge, England)
|December 16, 2015
PubMed
Summary

Small kinetochore-associated protein (SKAP) is vital for male gametogenesis in mice. SKAP deficiency impairs sperm production and testis size by affecting germ cell division and chromosome segregation.

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