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Related Experiment Videos

[In Process Citation].

Béla Hunyady1,2, Zsuzsanna Gerlei3, Judit Gervain4

  • 1Gasztroenterológia Osztály, Somogy Megyei Kaposi Mór Oktató Kórház Kaposvár, Tallián Gy. u. 20-32., 7400.

Orvosi Hetilap
|December 16, 2015
PubMed
Summary
This summary is machine-generated.

Over 70,000 people in Hungary have hepatitis C, many unaware. New direct-acting antiviral therapies offer over 90% efficacy for chronic hepatitis C treatment, improving patient outcomes and reducing healthcare costs.

Keywords:
asunaprevirboceprevirdaclatasvirdasabuvirdirect acting antiviral drugdirekt ható antivirális szerelbasvirgenotypegenotípusgrazoprevirhepatitis C virushepatitis C-vírushepatocellular cancerinterferonledipasvirliver cirrhosismájrákmájzsugorombitasvirparitaprevirpegilált interferonpegylated interferonpolimeraseinhibitorpolimerázgátlóprotease-inhibitorproteázgátlóribavirinritonavirsimeprevirsofosbuvirtelaprevirviral hepatitisvírushepatitis

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Area of Science:

  • Hepatology and Viral Gastroenterology
  • Clinical Pharmacology and Therapeutics
  • Public Health and Epidemiology

Context:

  • Approximately 70,000 individuals in Hungary are infected with the hepatitis C virus (HCV), with a significant portion unaware of their status.
  • Early detection and treatment of HCV-related liver injury are crucial to prevent advanced liver disease, including cirrhosis, liver failure, and liver cancer.
  • Socioeconomic benefits include preventing further viral spread and reducing the long-term financial burden of HCV morbidity.

Purpose:

  • To review the evolution and current landscape of hepatitis C virus treatment options in Hungary.
  • To highlight the efficacy of newer direct-acting antiviral (DAA) therapies compared to older interferon-based regimens.
  • To discuss the criteria and challenges associated with treatment eligibility and funding within the Hungarian healthcare system.

Summary:

  • Pegylated interferon plus ribavirin therapy achieved sustained virologic response (SVR) in 40-45% of treatment-naïve patients and 5-21% of treatment-failure patients.
  • Addition of first-generation protease inhibitors (boceprevir, telaprevir) improved SVR rates to 63-75% and 59-66%, respectively.
  • Since 2013, interferon-free DAA combination therapies demonstrate over 90% efficacy with short durations (8-12 weeks), representing a significant advancement in chronic hepatitis C management.

Impact:

  • Non-invasive methods like elastography and biochemical tests are preferred for staging liver fibrosis, guiding treatment decisions.
  • Accurate molecular diagnostics are mandatory for initiating therapy, with eligibility determined by central medical review.
  • Treatment access is limited by budget constraints, prioritizing patients based on a Hungarian Priority Index reflecting liver disease severity and other clinical factors.
  • Cost-effectiveness, based on cost per SVR, guides treatment selection, with potential for co-financing for more expensive regimens. Interferon-free treatments are prioritized within allocated budgets for eligible patients.