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Pediatric asthma and autism-genomic perspectives
Sunghee Oh1, Hong Ji2, Drew Barzman3
1Department of Computer Science and Statistics, Jeju National University, Jeju Ciy, Jeju Do, South Korea. sshshoh1105@gmail.com.
Clinical and Translational Medicine
|December 16, 2015
Summary
Genomic variations in autism and asthma are increasingly understood through high-throughput sequencing. These genetic changes offer potential biomarkers for personalized treatments and outcome prediction in pediatric disorders.
Area of Science:
- Genomics
- Pathobiology
- Biomarkers
Background:
- High-throughput technologies like microarrays and next-generation sequencing (NGS) are advancing disease pathobiology research.
- Genomic variations, including inherited and acquired mutations, are crucial in understanding human diseases.
- Autism and asthma are common chronic pediatric disorders with rising incidence and economic impact.
Purpose of the Study:
- To review genomic variations in autism and asthma.
- To highlight the role of genomic variations as potential disease biomarkers.
- To discuss the implications for personalized therapy and outcome prediction.
Main Methods:
- Review of current literature on high-throughput sequencing technologies.
- Analysis of genomic variations in autism and asthma.
- Exploration of gene expression regulation (pre- and post-transcriptional).
Main Results:
- Genomic variations are diverse, encompassing inherited, somatic, and germline mutations.
- Specific examples of genomic changes in autism and asthma are presented.
- Genomic variations are linked to disease-specific biomarkers.
Conclusions:
- Genomic variations are central to the pathobiology of complex diseases like autism and asthma.
- Understanding these variations can revolutionize disease cause identification and therapeutic development.
- Genomic biomarkers hold promise for personalized medicine and predicting patient outcomes.
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