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Work Capacity of the Bladder During Voiding: A Novel Method to Evaluate Bladder Contractile Function and Bladder
1Department of Urology, Beijing Jishuitan Hospital, Beijing 100035, China.
A new method simplifies calculating bladder work during voiding (WIV). Bladder work per voided volume (WIV/v) may indicate bladder outlet obstruction (BOO) severity, while WIV and WIV/t assess bladder function.
Area of Science:
- Urology
- Physiology
- Medical Engineering
Background:
- Work in voiding (WIV) offers a dynamic assessment of bladder function.
- Calculating WIV has been complex, limiting its clinical application.
- This study introduces a simplified method for WIV calculation and analysis.
Purpose of the Study:
- To develop and validate a method for calculating bladder work during voiding (WIV).
- To analyze associations between WIV parameters and bladder contractile function.
- To investigate the relationship between WIV parameters and bladder outlet obstruction (BOO).
Main Methods:
- Retrospective analysis of urodynamic data from 183 adult patients (160 men, 23 women).
- Utilized the bladder power integration method to calculate WIV, WIV per second (WIV/t), and WIV per voided volume (WIV/v).
- Statistical analysis included linear-by-linear and Spearman's association tests to correlate WIV parameters with detrusor pressure at maximal flow rate (PdetQmax), Abrams-Griffiths (AG) number, and BOO grade.
Main Results:
- WIV/v demonstrated significant positive associations with PdetQmax, AG number, and BOO grade in men.
- WIV and WIV/t did not show significant associations with PdetQmax or AG number.
- WIV/v correlated positively with increasing BOO grade in patients with obstruction.
Conclusions:
- The bladder power integration method provides a feasible way to calculate WIV from standard urodynamic data.
- WIV/v emerges as a potential non-invasive marker for assessing the severity of bladder outlet obstruction (BOO).
- WIV and WIV/t may serve as valuable indicators of intrinsic bladder contractile function.
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