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Tuberculosis-associated mortality in Shanghai, China: a longitudinal study
Weibing Wang1, Qi Zhao1, Zhengan Yuan2
1Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China .
People with tuberculosis (TB) in Shanghai face a significantly higher risk of death. Previously treated and smear-positive TB cases showed increased mortality, highlighting the need for early diagnosis and close monitoring.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Background:
- Tuberculosis (TB) remains a significant global health challenge.
- Understanding excess mortality in TB cohorts is crucial for public health interventions.
- Previous studies have indicated elevated mortality risks for TB patients.
Purpose of the Study:
- To determine the excess mortality associated with tuberculosis in a Shanghai cohort.
- To identify risk factors contributing to all-cause and TB-specific mortality.
Main Methods:
- A cohort of 4569 tuberculosis patients in Shanghai was established between 2004-2008.
- Mortality data was collected up to May 2014.
- Standardized mortality ratios (SMR) and Cox regression models were used to analyze mortality and associated factors.
Main Results:
- The overall SMR for all-cause mortality was 5.2, indicating a five-fold increase in deaths.
- Males exhibited a higher SMR (6.1) compared to females (3.0).
- Previously treated and sputum smear-positive TB patients had significantly higher risks of all-cause and TB-specific mortality.
Conclusions:
- Tuberculosis patients in Shanghai experience a substantially increased risk of mortality.
- Earlier diagnosis and enhanced follow-up strategies are recommended to mitigate mortality in this population.
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