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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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NHL - Extranodal T-cell lymphoma.

Seema Devi1, Richi Sinha2, Rakesh Kumar Singh2

  • 1Department of Radiation Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

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|December 16, 2015
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Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a rare cancer. This case report details a young female diagnosed with ENKL after initial misdiagnosis, highlighting the importance of accurate diagnosis.

Keywords:
Extranodallymphomanasal

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Area of Science:

  • Oncology
  • Hematology
  • Immunology

Background:

  • Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a rare lymphoid neoplasm.
  • ENKL is often misdiagnosed as granulomatous diseases.
  • Epstein-Barr virus (EBV) is strongly associated with ENKL, particularly in Asian populations.

Observation:

  • A 25-year-old female presented with a nonhealing ulcer on her nasal ala, upper lip, and cheek.
  • The ulcer persisted for two months despite antitubercular treatment.
  • Biopsy and immunohistochemical (IHC) analysis were performed.

Findings:

  • The patient was diagnosed with extranodal T-cell lymphoma.
  • Immunohistochemical analysis confirmed the diagnosis.

Implications:

  • Highlights the importance of considering rare lymphomas in differential diagnoses.
  • Emphasizes the need for accurate diagnostic methods like IHC for ENKL.
  • Underscores the challenges in diagnosing ENKL, especially in younger patients.