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Updated: Mar 28, 2026
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
[Not Available]
1Service de Réanimation Chirurgicale et des brûlés, CHU Nantes, France.
Abstract:
Local or general fungal infection remain a very serious event in burns. Burns have numerous risk factors for such, infections associated with depressed immunity. Candida, Aspergillus and mucor fungi prevail in wound infections. The two latest are especially serious and impairing. Diagnosis is based on anatomo-pathological and mycological examination of skin samples. Treatment is mainly surgical. Medical therapy depends on antifungal susceptibility. Most fungemias are candidemias. Diagnosis is difficult and often based on clinical suspicion. Treatment uses echinocandin and fluconazole.
Insights
Fungal infections, particularly from Aspergillus and mucor, pose serious risks in burn patients with weakened immunity. Diagnosis involves skin sample analysis, with treatment primarily surgical, supplemented by antifungal medications based on susceptibility.
Area of Science:
- Medical Mycology
- Burn Wound Infections
- Immunocompromised Patients
Context:
- Burns create significant risk factors for infections, especially in patients with depressed immunity.
- Fungal pathogens like Candida, Aspergillus, and mucor are prevalent in burn wound infections.
- Aspergillus and mucor infections present particularly severe challenges in burn care.
Purpose:
- To outline the diagnostic and therapeutic strategies for fungal infections in burn patients.
- To highlight the prevalence and severity of specific fungal agents in burn wound settings.
- To discuss the challenges in diagnosing and treating invasive fungal infections, including candidemia, in this vulnerable population.
Summary:
- Fungal infections are a major complication in burn patients due to compromised immunity.
- Diagnosis relies on anatomo-pathological and mycological examination of skin samples.
- Treatment is predominantly surgical, with medical therapy guided by antifungal susceptibility testing, often involving echinocandin and fluconazole for candidemia.
Impact:
- Improved understanding of fungal infection risks in burn patients.
- Enhanced diagnostic approaches for early detection of fungal pathogens.
- Optimized treatment protocols combining surgical intervention and targeted antifungal therapy for better patient outcomes.
