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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Association between colon diverticula and hemoglobin, triglyceride and uric acid levels
Minoru Tomizawa1, Fuminobu Shinozaki2, Rumiko Hasegawa3
1Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.
Insights
Colon diverticula are linked to lower hemoglobin and higher uric acid and triglyceride levels. These laboratory markers can help predict the presence of diverticula in patients.
Area of Science:
- Gastroenterology
- Clinical Chemistry
- Medical Diagnostics
Background:
- Colon diverticula are a common condition associated with significant gastrointestinal complications such as bleeding and acute diverticulitis.
- Predictive markers for diverticula presence are crucial for early diagnosis and management.
Purpose of the Study:
- To investigate the association between common laboratory test variables and the presence of colon diverticula.
- To identify specific laboratory thresholds that can predict diverticula presence.
Main Methods:
- Retrospective analysis of 1,520 patient records from April 2011 to March 2014.
- One-way analysis of variance and Chi-squared tests were used to assess associations.
- Receiver operating characteristic (ROC) analysis was performed to determine predictive thresholds.
Main Results:
- Patients with diverticula showed significantly lower hemoglobin (Hb) levels (P=0.0027).
- Higher uric acid (UA) (P=0.0066) and triglyceride (TG) (P=0.0136) levels were observed in patients with diverticula.
- A UA level ≥5.1 mg/dl was significantly correlated with a higher prevalence of diverticula (P=0.0004).
- ROC analysis identified predictive thresholds: Hb 12,400, TG 146 mg/dl, and UA 5.1 mg/dl.
Conclusions:
- Low hemoglobin, high triglyceride, and high uric acid levels are associated with the presence of colon diverticula.
- The identified laboratory thresholds can aid in predicting diverticula presence, potentially guiding further diagnostic investigations.
Abstract:
Colon diverticula cause bleeding and acute diverticulitis. The present study analyzed laboratory test variables, aiming to predict the presence of diverticula. Patient records from between April 2011 and March 2014 were analyzed retrospectively (1,520 patients) and a one-way analysis of variance was performed to analyze the association between the presence of diverticula and each variable. A χ2 test was then used to assess the correlation between the prevalence of diverticula and the percentage of patients with uric acid (UA) levels ≥5.1 mg/dl. A receiver operating characteristic (ROC) analysis was performed to determine the threshold values required to predict the presence of diverticula. Hemoglobin (Hb) levels were lower in patients with diverticula than in those without diverticula (P=0.0027), and compared with patients without diverticula, UA and triglyceride (TG) levels were higher in patients with diverticula (P=0.0066 and P=0.0136, respectively). The patients were divided into two groups, as follows: Patients with UA levels ≥5.1 mg/dl (the median value) and those with UA levels <5.1 mg/dl. The prevalence of diverticula was significantly higher in patients with UA levels ≥5.1 mg/dl than in those with UA levels <5.1 mg/dl (P=0.0004). ROC analysis demonstrated that the threshold values of Hb, TG and UA were 12,400, 146 and 5.1 mg/dl, respectively. The sensitivity of the Hb and UA levels at the threshold values was 76.5 and 71.0%, respectively. The prevalence of diverticula was associated with low Hb levels, and high TG and UA levels.
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