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Organic fluorides: implications for psychiatry.

R W Guynn, L A Faillace

    The Journal of Clinical Psychiatry
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Synthetic organic fluorides pose health risks, impacting psychiatry through therapeutic drugs and dangerous inhalant abuse. This review covers their biochemistry, toxicology, and psychiatric implications.

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    Area of Science:

    • Psychiatry
    • Toxicology
    • Biochemistry

    Background:

    • Synthetic organic fluorides are increasingly prevalent.
    • Concerns exist regarding their potential health hazards.
    • These compounds have significant implications in psychiatric medicine.

    Purpose of the Study:

    • To review the biochemistry and toxicology of organic fluorides.
    • To emphasize the implications of organic fluorides in psychiatry.

    Main Methods:

    • Literature review of organic fluorides.
    • Analysis of biochemical and toxicological data.
    • Focus on psychiatric applications and risks.

    Main Results:

    • Identified therapeutic organic fluorides: trifluoperazine, fluphenazine, triflupromazine, haloperidol, flurazepam.

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  • Highlighted indoklon as a polyfluorinated inhalant convulsant.
  • Noted the abuse of fluorocarbon aerosol propellants via inhalation.
  • Conclusions:

    • Organic fluorides present a dual role in psychiatry: therapeutic agents and substances of abuse.
    • Understanding their biochemistry and toxicology is crucial for psychiatric practice.
    • Further research is needed to mitigate risks associated with organic fluoride exposure.