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Persistence with mirabegron therapy for overactive bladder: A real life experience.
Nisha Pindoria1, Sachin Malde1, Jennifer Nowers1
1Department of Urology, Guy's Hospital, London, United Kingdom.
Neurourology and Urodynamics
|December 17, 2015
Summary
Persistence with mirabegron for overactive bladder (OAB) was 48% at six months. Early discontinuation was linked to lack of efficacy and adverse effects, with low overall patient satisfaction.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder (OAB) affects a significant patient population.
- Mirabegron offers an alternative treatment for OAB, particularly for patients intolerant to or unresponsive to anticholinergic therapy.
Purpose of the Study:
- To evaluate the persistence rates of patients undergoing mirabegron therapy for OAB over six months.
- To identify factors contributing to early discontinuation of mirabegron.
- To assess patient satisfaction with mirabegron treatment.
Main Methods:
- Retrospective analysis of hospital prescription data for mirabegron users.
- Review of case notes for demographic data, prior OAB treatments, and reasons for discontinuation.
- Assessment of treatment satisfaction using the OAB Satisfaction with Treatment Questionnaire (OAB-SAT-q).
Main Results:
- 197 patients were prescribed mirabegron; 81% had previously discontinued anticholinergic therapy.
- Persistence rates were 69% at 3 months and 48% at 6 months.
- Common reasons for discontinuation included lack of efficacy (48%) and adverse effects (32%). Only 39% of patients were satisfied with mirabegron.
Conclusions:
- Persistence rates for mirabegron in OAB patients are moderate.
- Unmet treatment expectations and adverse effects are key drivers of discontinuation.
- Further research is needed on mirabegron as a first-line treatment and in diverse OAB patient populations.
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