Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolonged paralysis associated with long-term pancuronium use.

J L Haas1, M S Shaefer, L J Miwa

  • 1Department of Pharmacy Practice, University of Nebraska Medical CenterOhama 68105.

Pharmacotherapy
|January 1, 1989
PubMed
Summary

Prolonged use of pancuronium bromide, a neuromuscular blocking agent, led to severe paralysis in a pediatric liver transplant patient. Acetylcholinesterase inhibitors reversed this neuromuscular dysfunction, suggesting a novel treatment approach.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survey of public attitudes towards imminent death donation in the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2020
Same author

The ASSURE study: HIV-1 suppression is maintained with bone and renal biomarker improvement 48 weeks after ritonavir discontinuation and randomized switch to abacavir/lamivudine + atazanavir.

HIV medicine·2015
Same author

Hepatic Homograft Survival in Pediatric Orthotopic Liver Transplantation with Cyclosporine and Steroids.

Transplantation proceedings·2010
Same author

Biliary Excretion of Cyclosporine in Liver Transplant Patients.

Transplantation proceedings·2010
Same author

Pediatric Liver Transplantation Under Therapy With Cyclosporin-A and Steroids.

Transplantation proceedings·2010
Same author

Biliary Tract Complications in Liver Transplantation Under Cyclosporin-Steroid Therapy.

Transplantation proceedings·2010

Area of Science:

  • Critical Care Medicine
  • Pediatric Neurology
  • Pharmacology

Background:

  • A 4-year-old patient underwent orthotopic liver transplantation and required mechanical ventilation for Pneumocystis carinii pneumonia.
  • The patient received pancuronium bromide, a neuromuscular blocking agent, for 40 days to facilitate ventilation.

Observation:

  • Following discontinuation of pancuronium, the patient developed severe, generalized neuromuscular dysfunction.
  • No improvement was observed for two weeks, necessitating further intervention.

Findings:

  • Administration of acetylcholinesterase inhibitors, edrophonium and pyridostigmine, resulted in clinical improvement.
  • Gradual recovery of neurologic function occurred over 3-4 months, returning the patient to baseline.

Related Experiment Videos

Implications:

  • Long-term pancuronium bromide use may cause prolonged neuromuscular dysfunction in pediatric patients.
  • Acetylcholinesterase inhibitors show promise as an antidote for pancuronium-induced paralysis.
  • This case highlights the importance of monitoring neuromuscular function during prolonged mechanical ventilation.